2026 NFL Week 10 Odds: Commanders and Giants Open a Slate of Tight Spreads

The NFL Week 10 schedule kicks off with a Thursday night clash between the Washington Commanders and the New York Giants, setting the stage for 14 matchups across the league. With four teams taking a mid-season break, a fresh set of 2026 NFL Week 10 odds is available for the remaining active franchises.

Thursday Night Football: Commanders vs. Giants

Washington heads to New York to open the Week 10 slate. At bet365 Sportsbook as of November 8, the Giants sit as slight 1.5-point favorites. The moneyline prices New York at -125 and the Commanders at +105, with the game's over/under total set at 43.5 points.

Tight Spreads Highlight the Weekend

Beyond Thursday night, several matchups feature lines of a field goal or less. The Carolina Panthers are 1.5-point favorites over the New Orleans Saints, with a moneyline of Panthers -120 and Saints +100, alongside a 47.5-point total.

Two games sit at a 2.5-point margin. The Detroit Lions are favored by 2.5 against the New England Patriots (Lions -142, Patriots +120, O/U 50.5), while the Indianapolis Colts lay 2.5 points against the Miami Dolphins (Colts -135, Dolphins +114, O/U 41.5).

Three-point spreads are prominent across the board:

• Chiefs vs. Falcons: Kansas City -3 (-175), Atlanta +145. Over/under: 46.5.
• Packers vs. Vikings: Green Bay -3 (-170), Minnesota +142. Over/under: 42.5.
• Seahawks vs. Raiders: Seattle -3 (-166), Las Vegas +140. Over/under: 42.5.

The Cincinnati Bengals are slightly higher at -3.5 against the Pittsburgh Steelers (Bengals -170, Steelers +142), with an over/under of 47.5.

Exploring the Over/Under Totals

The San Francisco 49ers and Dallas Cowboys matchup boasts the highest total of the week at 55.5 points. San Francisco is favored by 4.5 points (-225) over Dallas (+185). The Buffalo Bills and New York Jets follow closely with a 51.5-point total; Buffalo is an 8.5-point favorite (-550) over New York (+410).

On the lower end of the scoring projections, the Baltimore Ravens and Los Angeles Chargers clash has an over/under of just 38.5 points. Baltimore is favored by 4.5 points (-185) against Los Angeles (+154). The Houston Texans and Cleveland Browns also feature a sub-40 total at 39.5, with Houston laying 4.5 points (-192) against Cleveland (+160).

Largest Margins and Teams on Bye

The Jacksonville Jaguars hold the largest spread of the week, favored by 9.5 points (-500) against the Tennessee Titans (+380), with a total of 46.5. The Los Angeles Rams are 7-point favorites (-310) over the Arizona Cardinals (+250), with an over/under of 45.5.

Four teams will sit out the Week 10 action. The Chicago Bears, Denver Broncos, Philadelphia Eagles, and Tampa Bay Buccaneers are all on bye.